Laryngeal cancer is one of the most common cancers of the head and neck. The best diagnostic approach is provided by performing a full endoscopic evaluation, appropriate imaging and biopsy. Therapy can thereafter be tailored to pathology, stage of disease, and then individualized. The multidisciplinary tumor board represents an essential requirement in oncologic diagnosis and treatment, often introducing clinical challenges which force us to overcome our personal opinion in solving a case in a specific manner. This book represents a collection of our retrospective analysis of the local weekly tumor board which includes the otorhinolaryngologist, oncologist, radiotherapist, pathologist, radiologist and speech pathologist. We have also included reviews from national and international opinion leaders in the field of laryngeal cancer. The book is organized into three sections: basic science, diagnostic work-up and treatment, with the aim of providing a concise, up-to-date, and appropriate overview of the anatomy, risk factors, conventional and newest diagnostic management, open partial laryngectomies, laser CO2 transoral laryngeal microsurgery, and conventional and robotic total laryngectomy. The authors hope to procure a practical guideline for medical students, general practitioners, ENT specialists and, moreover, medical specialists whose roles are to provide the best up-to-date diagnostic and therapeutic management to patients with laryngeal cancer.